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dc.contributor.authorHawks Gutiérrez, Claudia Elizabeth
dc.contributor.authorElorza Barbajero, Jorge
dc.contributor.authorWitt, Annette
dc.contributor.authorLaroze Navarrete, David Nicolás
dc.contributor.authorRodríguez Cantalapiedra, Inmaculada
dc.contributor.authorPeñaranda Ayllón, Angelina
dc.contributor.authorEchebarría Domínguez, Blas
dc.contributor.authorBragard, Jean René Alfred
dc.date.accessioned2021-01-31T18:19:56Z
dc.date.available2021-01-31T18:19:56Z
dc.date.issued2019
dc.identifier.citationHawks Gutiérrez, C. E., Elorza Barbajero, J., Witt, A., Laroze Navarrete, D. N., Rodríguez Cantalapiedra, I., Peñaranda Ayllón, A., Echebarría Domínguez, B., y Bragard, J. R. (2019). Gap Junction Dynamics Induces Localized Conductance Bistability in Cardiac Tissue. International Journal of Bifurcation and Chaos, 29(8).es
dc.identifier.issn2181274
dc.identifier.urihttp://hdl.handle.net/20.500.12251/1548
dc.description.abstractConnexins are specialized ionic channels that control the action potential propagation between cardiac myocytes. In this paper, we study the connexin dynamics in a one-dimensional model of cardiac tissue. We show that the connexin dynamics may lead to a spatial organization of the gap junction conductance. In the numerical simulations presented in this paper we have found two different regimes for the spatial organization of the conductances: (a) a spatially uniform conductance; (b) a spatially complex pattern of local values of high and low conductances. In addition, we have observed that, locally, the two final states are limit cycles with a period equal to the period associated with the external excitation of the tissue strand. The conductance dispersion usually takes place on a very large time scale, i.e. thousands of heart beats, and on a very short spatial scale. Due to its simplicity, the one-dimensional setting allows a detailed study of the emerging structure and in particular very long simulations. We have studied the transition between the two aforementioned states as a function of the gap junction conductance characteristics. Furthermore, we have studied the effect of initially added noises on the outcome of the system. Finally, using spatial autocorrelation functions we have characterized the spatial dispersion in conductance values. © 2019 World Scientific Publishing Company.en
dc.language.isoeng
dc.publisherWorld Scientific Publishing Co. Pte Ltdes
dc.titleGap Junction Dynamics Induces Localized Conductance Bistability in Cardiac Tissueen
dc.typearticle
dc.identifier.doi10.1142/S0218127419300210
dc.issue.number8
dc.journal.titleInternational Journal of Bifurcation and Chaoses
dc.subject.keywordCorazónes
dc.subject.keywordConductanciaes
dc.subject.keywordTejido cardíacoes
dc.subject.keywordEnsayoes
dc.subject.unesco2411.03 Fisiología Cardiovasculares
dc.subject.unesco2410.10 Fisiología Humanaes
dc.subject.unesco2410.02 Anatomía Humanaes
dc.volume.number29


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