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Electrophysiological effects of small conductance Ca 2+ -activated K + channels in atrial myocytes

Identifiers
URI: http://hdl.handle.net/20.500.12251/1635
ISSN: 21993041
DOI: 10.1007/978-3-030-16585-7_2
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Author
Peñaranda Ayllón, Angelina; Rodríguez Cantalapiedra, Inmaculada; Álvarez Lacalle, Enrique; Echebarría Domínguez, Blas
Date
2019
Subject/s

Fibrilación auricular (FA)

Enfermedad del corazón

Salud

Unesco Subject/s

3201.04 Patología Clínica

3205.01 Cardiología

3207.04 Patología Cardiovascular

Abstract

Atrial fibrillation (AF), a cardiac arrhythmia characterized by an abnormal heart rythm originated in the atria, is one of the most prevalent cardiac diseases. Although it may have diverse causes, genetic screening has shown that a percentage of pacients suffering of AF present a genetic variant related to disregulation of calcium-activated potassium (SK) channels. In this paper we review the main characteristics of these channels and use several mathematical models of human atrial cardiomyocytes to study their influence in the form of the atrial action potential. We show that an overexpression of SK channels results in decreased action potential duration and, under some circumstances, it may give rise to alternans, suggesting a pro-arrhythmic role of this current. This effect becomes more important at higher pacing rates. Nevertheless, we also find it to protect against spontaneous calcium release induced afterdepolarizations, acting in this case as an antiarrhythmic factor. © Springer Nature Switzerland AG 2019.

Atrial fibrillation (AF), a cardiac arrhythmia characterized by an abnormal heart rythm originated in the atria, is one of the most prevalent cardiac diseases. Although it may have diverse causes, genetic screening has shown that a percentage of pacients suffering of AF present a genetic variant related to disregulation of calcium-activated potassium (SK) channels. In this paper we review the main characteristics of these channels and use several mathematical models of human atrial cardiomyocytes to study their influence in the form of the atrial action potential. We show that an overexpression of SK channels results in decreased action potential duration and, under some circumstances, it may give rise to alternans, suggesting a pro-arrhythmic role of this current. This effect becomes more important at higher pacing rates. Nevertheless, we also find it to protect against spontaneous calcium release induced afterdepolarizations, acting in this case as an antiarrhythmic factor. © Springer Nature Switzerland AG 2019.

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