Preparation of Alkyl-Substituted and Phenyl-Substituted Pyrimidines

Abstract

Vinyltrifluoromethanesulfonates (triflates) which are obtained from the corresponding ketones, react in an excess of pure nitriles (acetonitrile, propionitrile, benzonitrile) at 80°C (20h) to form substituted pyrimidines 5 and 8 in good yields. Vinyltriflates , which are obtained easily from the corresponding ketones, react in an excess of pure nitriles (80°C/20h) to form substituted pyrimidines in good yields.Vinyltrifluoromethanesulfonates (triflates) which are obtained from the corresponding ketones, react in an excess of pure nitriles (acetonitrile, propionitrile, benzonitrile) at 80°C (20h) to form substituted pyrimidines 5 and 8 in good yields. Vinyltriflates , which are obtained easily from the corresponding ketones, react in an excess of pure nitriles (80°C/20h) to form substituted pyrimidines in good yields.Vinyltrifluoromethanesulfonates (triflates) which are obtained from the corresponding ketones, react in an excess of pure nitriles (acetonitrile, propionitrile, benzonitrile) at 80°C (20h) to form substituted pyrimidines 5 and 8 in good yields. Vinyltriflates , which are obtained easily from the corresponding ketones, react in an excess of pure nitriles (80°C/20h) to form substituted pyrimidines in good yields.Vinyltrifluoromethanesulfonates (triflates) which are obtained from the corresponding ketones, react in an excess of pure nitriles (acetonitrile, propionitrile, benzonitrile) at 80°C (20h) to form substituted pyrimidines 5 and 8 in good yields. Vinyltriflates , which are obtained easily from the corresponding ketones, react in an excess of pure nitriles (80°C/20h) to form substituted pyrimidines in good yields.